過剰抗原による過敏性反応の抑制阻止に関する実験的研究 : 第1篇過剰抗原による皮膚アナフィラキシーの抑制に就て

概要

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When a fixed amount of anti-egg-albumin rabbit serum was injected intradermally in the passive cutaneous anaphylaxis in the guinea pig, reaction was intensified gradually with the increase of the concentration of egg-albumin reinjected intravenously. The maximal intensity of the reaction was observed at a definite concentration of antigen, but the higher concentration of the antigen did not increase but rather inhibite the reaction. The least concentration of antigen which induced the maximal reaction showed a tendency of higher concentration when the amount of the antibody was increased. The incubation periode became shouter and the duration of keeping sensitivity was prolonged with an increase in amount of antibody. Passively sensitizing capacity of the non-precipitable antibody sera was as that of the original sera, but it seemed that a tendcncy to be inhibited by the extremely excessive antigen was more remarkable in the former than in the latter.
日本アレルギー学会の論文
1960-04-01