アナフィラキシー・ショック死に関する実験的研究補遺 : 心電図・呼吸曲線・血圧及び病理組織像よりの検討
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概要
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Experimental Studies were carried out on the prolonging or the relief of life in anaphylactic shock, which is a typical pattern of the acute death. The author studied the process of it from the viewpoint of electrocardiogram, respiratory curve, blood pressure, and the pathohistological findings, but not a change was observed in the guinea pig relieved from the death. Kunito, a colaborator of the author, found that the course of the death in anaphylactic shock was acute asphyxia and succeeded in prolonging life of the animals by means of the mechanical and pharmacological method, but could not protect them completely and resulted them the delayed type of the death. The present author pointed out that the latter was due to the development of the secondary shock from the findings on the change of arterial blood gases, and established a method of the complete protection against the secondary shock. Similar curves of the blood pressure were obtained in the cases of the death due to anaphylactic shock and the acute asphyxia and the delayed type of death due to the chronic asphyxia. As to the respiration more prolonged inspiratory dyspnoea was observed than in the case of the acute asphyxia, and the characteristic rectangular waves were recognized in the delayed type of the death. It may be a course of dyspnoea, together with the contraction of the bronchi and atelectasis of the lung demonstrated histilogically and will play an important role in the development of the secondary shock, as in the case of the chronic asphyxia due to the forced respiration. In addition, the organs manifested the paren-cymatous changes as described in the literatures of the secondary shock in the case of the delayed type of death. On the other hand, in the case of death due to anaphylactic shock rupture of cardiac muscle was observed in the heart. This was a characteristic finding and it was also observed in the electrocardiogram myocardial injury appeared from the earlier stage. Not a common finding was observed between the death due to anaphylactic shock and the various types of shock.
- 日本アレルギー学会の論文
- 1960-01-01