血管内皮細胞における連結小胞およびチャネルの生成メカニズム (<小特集>バイオダイナミックス)

概要

論文の詳細を見る
The vascular endothelial cell vesicles are attached to both luminal and abluminal surfaces of the endothelium and contribute to the transport of specific macromolecules between the exterior environment and the cell. The vesicles mostly have flask-like or chained bead-like shapes, while they appear free within the cytoplasm and are essentially spherical. The existence of transendothelial channel, which is considered to be involved in specific transportation system, is also reported. In this study, generation mechanism of vascular endothelial chained vesicles and transendothelial channel is theoretically investigated based on a method proposed by J. C. Luke (1982). A system of nonlinear differential equations is derived according to the variational principle and is reduced to a two point boundary value problem. The equations are solved through the shooting method along with Newton-Raphson and Runge-Kutta method. The computed shape of the vesicle suggests that the chained vesicles and the cylindrical transendothelial channel are the most dynamically stable shape which can be formed in the vascular endothelial cell.
一般社団法人日本機械学会の論文
1997-03-25