Single Dose Radiocurability of Four Murine Solid Tumors and a Predictive Assay for the Curability in situ
スポンサーリンク
概要
- 論文の詳細を見る
Correlations between radiocurability and kinetic parameters were investigated in four transplantable tumor types in WHT/Ht mice. Tbe radiation dose to acbieve 50% tumor control at 120 days after irradiation,i.e., TCD_<50/120>, was 30 Gy for squamous cell carcinoma H, 32 Gy for squamous cell carcinoma NOS, 46 Gy for rhabdomyosarcoma KAS, and 63 Gy for fibrosarcoma YAS. The tumor cell kinetic parameters investigated were specific growth delay, volume doubling time, ^<125>I-iododeoxyuridine (IUdR) uptake rate, and specific cell loss rate. The specific cell loss rate was defined as the ratio of cell loss rate in non-irradiated tumors to the rate in irradiated tumors, and was obtained by measuring the retention rate of radioactivity in the tumors. No correlations were found between specific growth delay, volume doubling time, ^<125>I-IUdR uptake rate, and TCD_<50>. However, the specific cell loss rate correlated with the TCD_<50>. Therefore, the ^<125>I-IUdR labeling method may be useful as an in situ predictive assay for tumor radiocurability. What makes some tumors radiosensitive and others radioresistant? This question has vexed radiation oncologists and radiobiologists for years.
- 日本放射線影響学会の論文
著者
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Takai Yoshihiro
Department Of Radiology Faculty Of Medicine. Tohoku University
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Takai Yoshihiro
Department Of Radiation Oncology Tohoku Univ.
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Hosoi Yoshio
Department Of Radiation Oncology University Of Tokyo School Of Medicine
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Sakamoto Kiyohiko
Department Of Radiation Research Tohoku University School Of Medicine
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Sakamoto Kiyohiko
Department Of Radiology Faculty Of Medicine. Tohoku University
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HOSOI YOSIO
Department of Radiology, Faculty of Medicine. Tohoku University
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OKADA SIGEFUMI
Nuclear System Association
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Hosoi Yosio
Department Of Radiology Faculty Of Medicine. Tohoku University
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