Cellular effect of thermal neutron capture treatment using ^<10>B_1-para-boronophenylalanine: Lethal effect on melanoma cells with different degrees of X-ray sensitivity

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概要

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• We studied the effect of neutron capture treatment using ^<10>B-compound on X-ray sensitive P-39 and X-ray resistant G-36 1 human melanoma cell lines, and found a high lethal effect of boron neutron capture therapy in comparison with conventional ionizing radiation. The P-39 line was sensitive to thermal neutron radiation, and extremely sensitive to bleomycin treatment, whereas the G-36 1 line was resistant to both forms of treatment; however, the two cell lines had similar sensitivity to thermal neutron radiation after pretreatment with ^<10>B_1-para-boronophenylalanine (^<10>B1-BPA, 200 μg/ml medium). These results show that the thermal neutron capture products (a 7Li nucleus and alpha particle) are highly damaging and short range in tumor cells and thus more efficiently inactivate melanoma cells irrespective of x-ray sensitivity, than conventional X-ray-irradiation.

• 日本放射線影響学会の論文

著者

• Kobayashi Toru

  Research Reactor Institute, Kyoto Univ.

• TANO KEIZO

  Research Reactor Institute, Kyoto University

• UTSUMI HIROSHI

  Research Reactor Institute, Kyoto University

• KOBAYASHI TOORU

  Kyoto University Research Reactor Institute

• Utsumi Hiroshi

  Research Reactor Institute Kyoto University

• Utsumi Hiroshi

  Health Res. Foundation

• Utsumi H

  Kyoto Univ. Osaka Jpn

• Tano K

  Kyoto Univ. Osaka Jpn

• Tano Kaori

  Kyoto Univ.

• MIZUMA NAGAYO

  Research Reactor Institute, Kyoto University

• ICHIHASHI MASAMITU

  Special Institute of Cancer Neutron Therapy, Department of Dermatology, Kobe University School of Me

• Tano Keizo

  Research Reactor Institute Kyoto Univ.

• Ichihashi Masamitu

  Special Institute Of Cancer Neutron Therapy Department Of Dermatology Kobe University School Of Medi

• Utsumi H

  Research Reactor Institute Kyoto University

• Utsumi Hiroshi

  Research Reactor Institute

• Mizuma Nagayo

  Research Reactor Institute Kyoto University

• Mizuma Nagayo

  Research Reactor Inst. Kyoto Univ.

• Kobayashi Toru

  Kyoto University Research Reactor Institute

• Takimoto Koichi

  Faculty Of Agriculture Yamaguchi University

• Kobayashi Toru

  Research Reactor Institute Kyoto University

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