Radiation Carcinogenesis in the Whole Body System
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概要
- 論文の詳細を見る
In these last two days we have had our minds stimulated by facts and ideas, skillfully collated and presented by research workers for various countries. On your behalf, I would like to thank Dr. T. Sugimura, Dr. H. Tanooka and their colleagues, not only for the marvclous hospitality, but also for the successful manner in which this symposium has been organized and run. We will all go away with fond memories, new information and, no doubt, new ideas. On behalf of the organizing committee, I would like to thank the speakers who have done us proud in presenting their work with clarity and conveying the joy of research. One of the great values of symposia like this one is the exchange of views of researchers with quite different perspectives. This symposium has dealt with views based on work at every level of biological organization, from the molecule to the level of the human being. What did we hear at this symposium about radiation carcinogenesis? The spectrum of research in carcinogenesis is broad, and increasingly the approach is led by the developing technologies. This brief summary cannot do justice to all the papers, but hopefully will remind you of areas that you would like to learn more about when you go home. The opening address was given, appropriately, by S. Kondo (Kinki Univ. ). He discussed possible models that might apply to the multi-event process of radiation carcinogenesis. He suggested that dose responses for acute and chronic myeloid leukemia in the atomic bomb survivors differed, the latter having a threshold. In the case of acute myeloid leukemia, mutations of proto-oncogenes in hematopoietic stem cells could explain the response. The presence of a threshold response in chronic myeloid leukemia suggested that radiation acted on the stage operationally known as progression. Kondo thought that high doses of radiation caused a persistent disturbance in the cell renewal system. The implication was that radiation induced some cancers only at high doses above a threshold value by killing a critical number of stem cells. He proposed that the opening statement to the Symposium should be that carcinogenesis was the problem not just of a single cell but also of the society of cells.
- 日本放射線影響学会の論文