Dose-Response Relationship of Neutron and Gamma Rays to Chromosomally Aberrant Cells among Atomic Bomb Survivors in Hiroshima and Nagasaki

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The quantitative relationship of the frequency of cells with radiation-induced chromosome aberrations in peripheral leukocytes in atomic bomb survivors has been evaluated as a function of gamma and neutron doses. Three different models have been examined; each assumes a linear or a non-linear response to gamma rays and a linear-response to neutrons. From the standpoint of the goodness of fit of these models, the model which "best" fits the data on the frequency of cells with radiation-induced chromosome aberrations is the exponit model, where the frequency of aberrant cells increases exponentially with dose. The goodness of fit for this model shows the frequencies of cells with any chromosome aberration or an exchange aberration to be dependent cubically on the gamma ray dose and linearly on the neutron dose. The result derived from the frequency of aberrant cells gives a conservative dose-response relationship. The relative biological effectiveness (RBE) of neutrons for frequency of cells with any chromosome aberration is calculated to be 13 at 30 rad of neutrons, 6 at 100 rad, 3 at 300 rad and so on. The development of structural abnormalities in chromosomes following exposure to ionizing radiation has been repeatedly shown in experiments using animals and plants, and numerous studies document the types and frequencies of radiation-induced chromosome aberrations. Studies of atomic bomb survivors have revealed that aberrations are not only induced by ionizing radiation in the chromosomes of human peripheral leukocytes, but that they continue to exist for many years after radiation exposure even in persons who are clinically normal.
日本放射線影響学会の論文

Dose-Response Relationship of Neutron and Gamma Rays to Chromosomally Aberrant Cells among Atomic Bomb Survivors in Hiroshima and Nagasaki

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