Radiotherapy Combined with Hypertbermla : The Fractlonation Problem
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概要
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The interaction of heat with ionizing radiation in normal and cancer cells is analyzed. The factors affecting the thermal enhancement ratio (TER) are discussed. From the data available in the literature it is concluded that heat could selectively inhibit repair of radiationinduced sublethal damage in cancer cells. Using appropriate fractionation schedules this could be utilized to improve the current efficacy of tumor control by radiotherapy. In recent years attention has been focused on hyperthermia, either alone or in combination with radiation and drugs, as a potential modality in the treatment of cancer (for recent reviews see ref. ). Since radiotherapy is given in many fractions, for application of combined hyperthermia and radiation in the clinic we need information on the interaction of heat with fractionated irradiation. Up to now very little work dealing with this subject has been published. The purpose of this paper is to put the available data in a more comprehensive framework and to point out the possible conclusions from an analysis of the data in such a framework. Work with cells in culture established three basic cellular mechanisms underlying the enhancement of radiation response by heat. (a) Heat inhibits the capacity of mammalian cells to reparr sublethal damage. (b) Heat inhibits repair of radiation-induced potentially letal damage. (c) Heat potentiates the radiation response of hypoxic cells (which are radiationresistant) more than that of oxic cells. The basis for this phenomenon, which is obviously beneficial for the radiotherapist, could be either the low pH or/and nutritional deficiency of such cells. Low oxygen tension per se does not seem to be important in this regard.
- 日本放射線影響学会の論文
著者
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Ben-hur E.
Department Of Radiobiology Nuclear Research Center-negev
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HAZAN G.
Department of Radiotherapy, Beilinson Hospital
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Hazan G.
Department Of Radiotherapy Beilinson Hospital