Effects of Tritiated Water on Mice Liver, in Relation to Age
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概要
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Tritiated water was administered intraperitoneally at the dose rate of about 20 μCi/ml of body water to different six age groups of Swiss albino mice, ranging from 1 to 6 weeks old. They were autopsied at 48 hours post-injection. The liver of 5 weeks old mice is found most vulnerable and that of 4 weeks second but lesser than 5 weeks. Histopathologically, 1, 2, 3 and 6 weeks old mice liver showed lesser degree of damage. The distinct histopathological lesions include oedema, cytoplasmic vacuolation and degranulation, hyperaemia, increase number of Kupffer's cells etc. Tritium, a naturally occuring heavy isotope of hydrogen (Half-life 12.3 yrs ; at. weight 3) is formed from several interactions of cosmic rays with the gases of upper atmospheric nitrogen. Moreover, large quantities of tritium are also involved in nuclear energy operations and, being a significant by-product of nuclear fission finds its way into the environment. These gradually increasing amounts may prove hazardous to animal population including man. Since the general population includes potentially radiosensitive groups or individuals, the dose limits for an individual in the general population has been set at a factor 10 below those for radiation workers. However, as pointed out in ICRP Publication 9, no undue biological significance should be attached to the magnitude of this factor because the radio-biological information to assess this safety factor is inadequate.
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