Influence of Ovariotomy on Recovery of Thymus Following X-ray lrradiation fn ICR/JCL Mice

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Ovariotomy in 8 week-old, specific pathogen free ICR/JCL mice was effective in securing a marked thymus regeneration following a single whole body irradiation with 300 rads of X-ray. Recovery of the bone marrow cell counts, especially of the lymphoid cells, preceded the thymus regeneration and was more marked in spayed mice than in the sham-operated. On the basis of these results, it is suggested that ovarian hormones play a role in the thymic lymphopoiesis by affecting the dynamics of the lymphoid stem cells in the bone marrow and/or the lymphopoietic microenvironments in the thymic cortex. The thymus is highly sensitive to various stressful stimuli, usually resulting in an acute atrophy or involution (lymphocyte depletion) of various degrees in proportion to the intensity of the stimuli. Many of these stimuli, such as ionizing irradiation, infections and malnutrition, act as lymphocytolytic agents either directly or indirectly via the enhanced release of adrenal glucocorticoids. Thymic involution has also been described as a normal accompaniment of pregnancy and lactation.
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