Studies on Time Factors in Irradiation Factors in Dose Fractionation on Lethal Effects on Mice

概要

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The relationship of time factors (number of fractions, dose per fraction and intervals between fractions) and the lethal effects on mice was examined by fractionated whole-body irradiation 1) by changing the number of fractions and the dose per fraction with a constant average dose per one day, 2) by changing the dose per fraction with a constant interval between fractions, and 3) by changing the intervals between fractions with a constant dose per fraction. When a fixed average dose per one day was given, irradiation with a large dose per fraction and small number of fractions was found to be more lethal than that with small dose per fraction and large numbers of fractions. When the irradiation was given with a constant interval between exposures, the total dose necessary for 50% mortality increased with increasing dose per fraction in a range from 100 R to 600 R. When the irradiation was given with constant dose per fraction and different intervals between fractions, a decrease in lethal effects was observed with increasing intervals between exposure.
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