圧縮錠剤の吸湿による膨張

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概要

• 論文の詳細を見る

• The expansion of the compressed tablets in diameter and thickness due to their sorption of moisture has been studied, using starch and microcrystalline cellulose tablets. Of the starch tablets, the values of equilibrium volume expansion were very low as compared with the equilibrium moisture contents at low relative humidities below 20%. Above this relative humidity, the values of volume expansion were approximately at 1 cm^3 per gram of the sorbed water. In the kinetic measurement under different conditions of relative humidity, the rate constant of moisture sorption increased with increasing relative humidity. The values of rate constants of volume expansion were approximately equal to those of moisture sorption. For the microcrystalline cellulose tablets both the rate of moisture sorption and the rate of volume expasion decreased with increasing compaction pressure in tablet preparation.

• 社団法人日本材料学会の論文
• 1969-06-15

著者

• 脇本 彪

  Toa Pharmaceutical Industrial Co. Ltd.

• 脇本 彪

  東亜医薬品工業(株)

• 竹田 明美

  東亜医薬品工業株式会社

• 大塚 昭信

  名古屋大学薬学部

関連論文

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• 「薬学会の総会・分科会制度の是非」のパネルを読んで : その1
• Moisture Sorption and Volume Expansion of Amorphous Lactose Tablets
• 無水乳糖錠の吸湿と膨張
• 圧縮錠剤の吸湿による膨張

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