Nitrosourea系抗癌剤ACNUによる悪性脳腫瘍の治療

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For the purpose of treatment of brain tumors with ACNU [1-(4-amino-2-methyl-5-pyrimidinyl) methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride], inhibitory effects on tumor cell proliferation in vitro, pharmacokinetics, clinical responses and side effects of the drug were investigated.ED_<50> of ACNU for KS-1 cells was 25 μg/ml.Generally, glioblastoma cells were more sensitive to ACNU than meningioma cells.After intravenous injection of ACNU 100-150 mg/body, in 14 patients with brain tumors, transition of the drug into cerebrospinal fluid was noticed at 5 minutes in all cases with the maximum valus of 0.59+0.13μg/ml at 30 minutes.The therapeutic effects of the drug were evaluated in 31 patients with brain tumors by neurological and CT-scan exminations.Combined chemo-radiotherapy with ACNU, FT207 and Tele-cobalt was more effective than ACNU therapy alone;36% of the patients were "improved" in our criteria, although hematologic toxicity of ACNU was obsetved in 55%
日本脳神経外科学会の論文
1979-12-15