Potential Protection by a Specific Kappa-opiate Agonist U-50488H Against Membrane Failure in Acute Ischemic Brain

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概要

• 論文の詳細を見る

• The effects of a novel opioid K-receptor agonist U-50488H on Na^+-K^+-adenosine triphosphatase (AT-Pase) activity and regional cerebral blood flow (rCBF) were studied in the acute ischemic brain of rats after middle cerebral artery (MCA) occlusion. Administration of U-50488H 15 minutes prior to MCA occlusion attenuated ischemic reduction in Na^+-K^+-ATPase activity 15 minutes after MCA occlusion. The effect was statistically significant at a dosage of 30mg/kg, but not at lower doses (0.3 and 3mg/kg). There was no effect on rCBF before MCA occlusion, and the decreased flow after occlusion was enhanced with a significant fall in systemic blood pressure at a dosage of 30mg/kg. These results indicate that U-50488H has therapeutic potential in cerebral ischemia by mechanisms other than improvement in CBF.

• 日本脳神経外科学会の論文
• 1993-03-15

著者

• FURUI Tomoo

  Department of Neurosurgery, Meijo Hospital

• Furui Tomoo

  Department Of Neurosurgery Aichi Medical University

• Furui Tomoo

  Department Of Neurological Surgery Aichi Medical University

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• Potential Protection by a Specific Kappa-opiate Agonist U-50488H Against Membrane Failure in Acute Ischemic Brain
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