Effects of Moderate Hyperthermia on the Rabbit Sarcoma Model

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概要

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• A method of induction of moderate hyperthermia with a plate heater and a direct current energy source was investigated in the VX-2 rabbit sarcoma model. The theoretical distribution of temperature in the rabbit brain was calculated under various heating conditions. The calculated temperatures coincided well with the temperatures of moderate hyperthermia measured by a thermocouple to a depth of 7 mm under the heater. Moderate hyperthermia was induced in the VX-2 sarcoma. Hyperthermia at 40℃ for 20 minutes caused no changes in the lesion. Hyperthermia at 45℃ for 20 minutes destroyed the lesion partially to a maximum depth of 3 mm, Hyperthermia at 50℃ for 20 minutes caused greater destruction, but also caused edema in the lesion and the surrounding normal brain. Hyperthermia at 55℃ for 20 minutes caused severe damage in both the lesion and the surrounding normal brain. Comparison of the actual destruction by hyperthermia and the theoretical temperature distribution indicated that hyperthermia at 43℃ for 20 minutes was effective against brain tumor, and destruction reached at least 3 mm from the heater.

• 日本脳神経外科学会の論文
• 2003-03-15

著者

• KOBAYASHI HAJIME

  Department of Biotechnology, Graduate School of Engineering, Osaka University

• AOYAGI Norio

  Department of Neurosurgery,Bokuto Municipal Hospital of Metropolitan Tokyo

• Aoyagi Norio

  Department Of Neurosurgery Bokuto Municipal Hospital Of Metropolitan Tokyo

• Aoyagi Norio

  Department Of Neurosurgery Moriyama Hospital

• TAKAKURA Kintomo

  Tokyo Women's Medical College

• TAKEMURA Nobuhiko

  Department of Neurosurgery, Tokyo Metropolitan Bokuto General Hospital

• Takemura Nobuhiko

  Department Of Neurosurgery Tokyo Metropolitan Bokuto General Hospital

• Kobayashi Hajime

  Department Of Agricultural Information Science Faculty Of Agriculture Tottori University

• Kobayashi Hajime

  Department Of Mechano-informatics The University Of Tokyo

• Takakura Kintomo

  Tokyo Women's Medical University

• Takakura Kintomo

  Tokyo Women Medical College

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