KINETIC MOVEMENT OF FIBRIN MONOMER AND ITS SURROUNDINGS IN NEWBORN ASPHYXIA : ESPECIALLY ON THE RELATIONSHIP OF SOLUBLE FIBRIN MONOMER COMPLEX (S.F.M.C.) AND DISSEMINATED INTRAVASCULAR COAGULATION

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1) (Purpose): Hemorrhage in the new born period especially intracranial hemorrhage and lung hemorrhage in RDS is highly problematic in the field of obstetrics as the cause of deaths in the perinatal period. In newborn asphyxia and immature babies some cases show definite signs of hypercoagulability was remarkably noted, and the attempt to investigate the relationship between the so-called dissminated intravascular coagulation and asphyxia in the newborn, fibrin monomer was measured in the form of soluble firbin monomer complex (S.F.M.C) was performed. In addition, investigation of the factor XIII, and changes of the α-chain of fibrinogen which exerts a serious influence on both blood coagulation and fibrinolytic systems was observed. The efforts were made to grasp the course of the disease in the newborn starting from hypercoagulability and proceeding to disseminated intravascular coagulation (DIC). 2) (Method): 54 cases of newborn were studied. These were divided into the 3 following groups, namely (i) Apgar≦4 (ii) 5≦Apgar≦7, (iii) Apgar>7, SFMC measurements were made by agarose gel-filtration on cord venous blood and newborn blood. Respective fraction obtained in changes of α, β, γ chains in fibrinogen were measured by electrophloresis and the relationships with the factor XIII was followed. 3) (Results): As regards SFMC, in the Apgar≦4 groups the value was 5.68±1.98% which is a remarkable increase over the value of 3.17±0.55% of the normal group and a reversed correlation (γ=-0.73) was recognized against the Apgar score. Thus, it was clearly shown that from quantitative measurements of newborn asphyxia hypercoagulability was present. As a result of PAA electrophloresis in the DIC group, a characteristic of α chain in the fibrinogen namely the decreses of α chain was seen, and at the same time a decrease in the factor XIII was noted.
社団法人日本産科婦人科学会の論文
1977-12-01

KINETIC MOVEMENT OF FIBRIN MONOMER AND ITS SURROUNDINGS IN NEWBORN ASPHYXIA : ESPECIALLY ON THE RELATIONSHIP OF SOLUBLE FIBRIN MONOMER COMPLEX (S.F.M.C.) AND DISSEMINATED INTRAVASCULAR COAGULATION

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