Hyaluronidaseと腦下垂體前葉機能
スポンサーリンク
概要
- 論文の詳細を見る
Nothing much has yet been made known concerning the relation between hyaluronidase (hereafter abbreviated H.D.) and the function of the anterior pituitary lobe as well as that of other kinds of hormones. To make this point clear, researches have been carried out on the relation between the secretion of H.D. contained in the skin of frogs (Rana nigromaculata) and the function of the anterior pituitary lobe as well as that of other types of hormones, with the following results. 1. Amount of H.D. contained in 1g of the skin of a normal frog is quite constant, ranging from 700 V.U.M. to 900 V.U.M., regardless of the sex of the frog. 2. Remarkable increase of H.D. contained in the skin can be noted as a result of the removal of the anterior pituitary lobe, reaching double the usual amount in 2.5 days and 3 to 4 times in 5 days. 3. Increase in H.D. secretion caused by the removal of the anterior pituitary lobe returns to normal along with the administration of an anterior pituitary extract, gonadotropin, but remains unchanged by ACTH, so that it may possibly be concluded that H.D. secretion is controled and regulated by gonadotropin. 4. In frogs deprived of anterior pituitary lobe, increase in H.D. secretion was accelerated by thyradin and epinephrin, especially by the latter, whereas inhibitory action was observed in some sex hormones such as estrone, ethinyl estradiol, progesterone, and testosterone propionate, or oil-soluble as well as water-soluble (Interenin), adrenal cortical extract, DOCA and insulin. 5. In normal frogs, amount of skin-contained H.D. is not influenced by the administration of any kind of hormones.
- 1952-05-01