アブレル氏人工妊娠中絶術に關する基礎的研究

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(1) In the histo-pathological studies of 22 cases of placenta as well as the main organs of fetuses artificially delivered by the Aburel's method, that is infusing 100 cc of saturated salt solution into an amniotic cavity, eminent degenerative changes could be observed both in the placenta and the main fetal organs ; for instance congestion, thrombus formation beneath embryonic membrane, degeneration of chorion, remarkable fibrination in the placenta and the marked regressive changes in liver, kidney, heart and lung in the fetal organs. (2) Infusing solutions of saturated salt, 30% or 50% glucose, 40% magnesium sulfat and aqua dest. respectively into the abdominal cavity of mice, and studying their main organs after they are dead or killed, remarkable regressive changes were also recognized in their parenchymatous organs such as liver, kidney, heart or lung. (3) Into the embryonal sack of pregnant rabbits the same amounts of saturated salt solution (1. group), the solution of 30% glucose (2. group) and that of 40% or 30% MgSO_4 (3. group) were respectively infused. After that 3 rabbits out of 5 died in the 1st group, while 1 out of 6 in the 2nd and 2 out of 5 in the 3rd group also died respectively. The most part of those rabbits were found carrying dead fetuses in their uterine cavity. Liver, kidney, heart and lung of those rabbits were subject to considerably strong degenerations, while the placentas showed prominent changes similar to those found in mice ; above all, degeneration in syncytium cell was remarkable. The changes in their fetal organs coincided with those in the human fetus. (4) In the placenta and the corpus luteum of those rabbits submitted to the Kon's silver reaction the silver granules were found remarkably decreased in amount as compared with those of the normal pregnant rabbits, From this fact it is most likely that the endocrine functions of the placenta and the ovary are markedly affected by the Aburel's method so that the secretion of the corpus luteum hormone and the chorionic gonadotropin are diminished, often resulting in the development of the delivery. Conclusion (1) By means of the Aburel's method the normal pregnancy is artificially interrupted, probably due to the decrease of the secretion of the corpus luteum hormone and the chorionic gonadotropin as a result of the action of the solutions of the saturated salt etc., on the ovary and the placenta. (2) The Aburel's method cannot be applied to a pregnant woman complicated with disorders of liver, kidney, heart or lung. (3) After the 8th month of pregnancy the Aburel's method is not applicable for the induction of delivery.
社団法人日本産科婦人科学会の論文
1952-02-01

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和歌山縣立醫科大學産婦人科學教室:和歌山縣立醫科大學病理學教室

アブレル氏人工妊娠中絶術に關する基礎的研究

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