子癇の成因に關する血清學的研究第2報 : 家兎胎盤による同種抗體の産生について

概要

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In 1907 Frank reported for the first time that a rabbit immunized with the extract of the rabbit placenta produces no isoprecipitin, and later both Saheki and Akibo also failed to obtain it in the same experiment. Ishikawa, however, succeeded in obtaining it in 1928. In recent years Magara described about the possibility of the production of the isogenic antibodies in rabbits immunized with the extract of the rabbit placenta in combination with the staphylococcus-toxin. In the present experiment concerning the production of isogenic antibodies following the injection of homologous placenta emulsion the following results were obtained. 1) The isogenic precipitins were produced in the rabbit's serum in response to the injection of the extract of the rabbit placenta. 2) The isogenic antibodies such as precipitins against the placental extract have high grade of organ as well as species specifity, the antigenity of which being presumably attributable to the myoglobin like substance of the placenta. 3) Such isogenic antibodies against the myoglobin like substance of the pacenta may be considered most responsible for the toxemia of pregnancy such as preeclampsia or eclampsia.
社団法人日本産科婦人科学会の論文
1951-12-01