子宮筋腫の病態と治療
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概要
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The pathogenesis of uterine leiomyoma is controversial. Studies on the development of smooth muscle cells in the endoderm-derive ducts (digestive and urinary tracts) and in the mesoderm-derived ducts (mullerian duct) during the fetal period revealed that the development of smooth muscle in the mesoderm-derived ducts (until at least 30 weeks of gestation) is slower than that of smooth muscle in the endoderm-derived ducts (until 12 weeks of gestation). The undifferentiated cells which proliferate and differentiate into smooth muscle in the uterus during the fetal period thus have a longer duration of unstable period being affected by many maternal environmental factors such as sex steroids and/or growth factors. The undifferentiated cells affected by some unknown maternal factors during the fetal period probably become the progenitor cells of leiomyomas. The progenitor cells of leiomyomas probably reside in the myometrium and begin to grow after menarche, and thrive during the years of greatest ovarian activity under the hormonal influence of both estrogen and progesterone, and following the menopause, with regression of ovarian steroids, growth of leiomyomas usually ceases. The growth pattern of leiomyomas indicates that LH-RH analogue, which induces temporal regression of ovarian steroids, becomes one of candidates for the conservative treatment of uterine leiomyomas. However, if we may treat leiomyomas with drugs, the definite diagnosis of uterine leiomyoma is essential. Magnetic resonance imaging (MRI) is a powerful diagnostic method for uterine leiomyomas. MRI gives us an information of the location and numbers of leiomyoma in the uterus. Moreover, it also informs us the characteristics of leiomyomas. Consequently, the diagnosis of leiomyomas by MRI is very important if we may treat leiomyoma patients with LH-RH analogue. The results treated with LH-RH analogue for 4 months informed us that some nodules regress but others do not. However, this treatment improves anemia and symptoms of leiomyoma patients. Consequently, before we perform surgical treatment, the treatment of leiomyoma patients for 4 months with LH-RH analogue gives us benefit to avoid blood transfusion at operation. In addition, we now have an opportunity to take care of leiomyoma patients with this drug in outpatient clinics. Primarily uterine leiomyomas are clinically benign disease. The indication of surgical treatment for leiomyomas lies our vague information on differential diagnosis between uterine sarcomas and leiomyomas. Therefore, further development of diagnostic method for uterine leiomyomas is very important for the conservative treatment of uterine leiomyomas.
- 1992-08-01
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