肝門部リンパ流遮断時の感染防御能に関する実験的研究

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For the purpose to investigate the influence of interruption of the lymphatic drainage from the liver, we designed experimental study by ligating the lymph vessels in the porta hepatis of mongrel dogs and observed its effects on reticuloendotherial system (RES) function and hepatic microcirculation. The follwing results were obtained. 1) Two weeks following ligature of the lymph vessels there was a significant depression in Kupffer cell phagocytic and bacteriocidal function. Additional common bile duct ligation markedly depressed this function even further. 2) When lipopolysaccharide of E. coli was injected into the bile duct of mongrel dogs with thoracic duct drainage, endotoxin shock was not induced at an intrabiliary pressure of less than 25cmH_2O but was induced at an intrabiliary pressure of 35cmH_2O or more. When the lymph vessels were ligated, endotoxin shock could be induced at an intrabiliary pressure of less than 25cmH_2O. 3) To study the role of hepatic lymphatic system as RES, lipopolysaccharide was injected into the hepatic lymph vessel and thoracic duct lymph sample was collected. It was found that 60 to 70 per cent of injected lipoplysaccaride was cleared from lymph. It was suggested that ligation of the lymph vessels in the porta hepatis would depress RES function, induces the spill over phenomenon from the hepatic lymphatic system, and impair the local host defense of the liver.
1988-12-20