神経芽腫群腫瘍におけるN-myc癌遺伝子の増幅と予後 : とくにN-myc増幅と従来の予後因子との相関性について

概要

論文の詳細を見る
N-myc oncogene of 29 neuroblastic tumors was measured and compared with known prognostic factors. The number of patients with the N-myc amplification of more than 3 copies was 17 (59%), and that of more than 11 copies was 11 (38%). All the fatal cases had more than 11 copies of N-myc. The amplified N-myc was observed in cases with advanced stages, suprarenal origin and the age of 1 to 4 years. However, the correlation with histology could not be found. The patients who had received preoperative chemotherapy but whose tumor could not be completely removed had a tendency to have an amplified N-myc. Thus, the genomic amplification of N-myc seemed to be a new clinically useful prognostic factor of neuroblastoma in children.
特定非営利活動法人日本小児外科学会の論文
1987-08-20