マスフラグメントグラフィーによる先天性胆道閉鎖症の血清胆汁酸測定 : 特に未同定 dihydroxy 胆汁酸と予後の関連について

概要

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The serum bile acids in congenital biliary atresia (CBA), neonatal hepatitis and controls were measured by the gaschromatography/mass spectrometry (GC-MS). The concentration of total bile acids in control group was 1.49 ± 1.01μg/ml in the age of 1-12 months, and was 1.17±0.83 μg/ml in the age over one year. The concentration of total bile acids in preoperative congenital biliary atresia and neonatal hepatitis were over ten times higher than that of control group. There was no difference between neonatal hepatitis and preoperative CBA in the concentration of total bile acids and choli acid/chenodeoxycholic acid (C/CDC) radio. The concentration of ursodeoxycholic acid was high in a case of neonatal hepatitis and a case of preoperative CBA. The existence of unidentified dihydroxy C_24 bile acid was recognized in the serum of neonatal hepatitis and CBA in this study. The concentration of unidentified dihydroxy C_24 bile acid showed high levels in neonatal hepatitis and preoperative CBA, especially in postoperative CBA with poor-drainage. Therefore this unidentified dihydroxy C_24 is considered to be produced through alternative pathway in the liver.
1986-11-02