A Loose Coupling Mechanism of Synthesis of ATP by Proton Flux in the Molecular Machine of Living Cells

概要

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A loose coupling mechanism is proposed for the molecular machine of livingcells which performs the synthesis of ATP from ADP and inorganic phosphate bya proton flux across the membrane. The basic assumption is that a torque orrotational movement is produced in protein molecules by the proton flux and theATP synthesis is promoted by the torque or rotational movement in the molecules.The first process is carried out by a mechanism similar to the bacterial flagellarmotor where the coupling between the flow of protons and the rotation of themotor is loose. A structural model for the second process is also presented. Thethreshold of the potential difference of proton for the ATP synthesis can be lowand the number of protons to synthesize one ATP molecule is not an integer but avariable number.
社団法人日本物理学会の論文
1984-04-15