ラットの激運動後における乳酸の酸化

概要

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Oxidation of lactate at rest (RE, n=4), or after short strenuous exercise (EX, n=6) was investigated in rats. Food and water were given ad libitum before experiment. In EX, rats ran to exhaustion at the speed of 80-100 m・min^<-1>. Immediately after exercise, 4 μCi of[U-^<14>C] lactate was injected into aorta through an indwelling catheter. In RE, [U-^<14>C] lactate was injected into the rats at rest. Expired gas was collected by a Brooks type bottomless chamber on treadmill belt for 120min. In EX, exercise duration was 109±18 sec (mean±SE), and maximum blood lactate concentration after the exercise was 23.7±2.1 mM (mean±SE). Cumulative percent recovery of ^<14>C as ^<14>CO_2 for 120 min was 48.5±2.8% for EX and 61.7±0.9% for RE (mean±SE). Significant difference was found between these two rates (p<0.01). After 50 min of recovery, mean volume of ^<14>CO_2 expired per min in RE was significantly greater than that in EX(p<0.01). Mean volume of ^<14>CO_2 expired per min per VCO_2 in RE was always greater than that in EX, and significant difference was found at 7.5 min of recovery (p<0.01). It is concluded that although the rate of recovery of ^<14>C as ^<14>CO_2 after exercise is lower than that at rest, the major pathway of lactate metabolism after short strenuous exercise is oxidation.
日本体力医学会の論文
1986-04-01