筋収縮時伸長にともなう筋繊維の傷害発生 : 発育期の収縮特性と構造変化

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A study was conducted to investigate the influence of a series of quick stretches during tetanic stimulation of skeletal muscle fibers in growing mice. Mice were anesthetized with pentobarbital sodium. The distal tendon of the extensor digitorum longus muscle was attached to a servomotor. The effects on the muscles of a series of isometric contractions (ISO), a series of quick stretches during contractions (ST), and a sham operation for 1 h were assessed in terms of changes in tetanic tension, serum creatine kinase and lactate dehydrogenase activities, and the histological appearance of the muscle. The data indicated the following ; 1) Serum enzyme activities were not altered in any of the experiments. 2) ST resulted in a decrease in tetanic tension compared with ISO values in mice of all ages. The rate of decrease in tetanic tension for 1 h ST was higher in muscles of young mice than in those of mature mice. 3) Muscle histology demonstrated numerous areas of localized sarcomere widening immediately after the series of ST. These observations suggest that muscle stretching during contraction causes greater injury to developing skeletal muscles. (Jpn. J. Phys. Fitness Sports Med. 1990, 39 : 324～330)
日本体力医学会の論文
1990-10-01