Interactions of Plasma Proteins and Polymeric Materials

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概要

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• It has been recognized that some proteins combine with natural and synthetic polyelectrolytes and form a precipitate or soluble complex, even in the physiological pH region where both of them have negative net charges. This phenomenon has been investigated by several authors from various stand-points. Physicochemical analysis concerning the mechanism of such interaction between proteins and polyelectrolytes is now in progress. According to recent experimental results, plasma proteins-serum albumin and fibrinogen-do not combine with macromolecules which carry no electric charges on them. Further, it has been found that the binding ability of polyelectrolyte to protein is influenced greatly by the sort of ionizable groups on them, that is, polyelectrolytes carrying -SO_3^- groups have the stronger binding affinity to protein molecules than those carrying -COO^- groups. Therefore, among ionized groups on polyelectrolyte there is a specificity for the interaction with proteins. Hitherto, it has generally been stated that the interaction between macromolecules is caused by the van der Waals force, but this force is not adequate to explain the interaction of protein with polyelectrolyte. The electric charges on proteins and polyelectrolytes play a role in their interaction, and therefore the interaction can be analysed by introducing the electrostatic force based on the Debye-Huckel theory. As a results it is suggested that the charge distribution on the protein can play an important role in the interaction with polyelectrolyte. For the purpose of explaining the specificity observed among ionizable groups, it is necessary to introduce the hydrogen bond between amino residues of protein and ionizable groups of polyelectrolyte, then the experimentally obtained results can be mostly interpreted.

• 理論物理学刊行会の論文

著者

• NOGUCHI Hajime

  Department of Chemistry, Keio University

• Noguchi Hajime

  Department Of Physics Aichi-gakugei University

• NOGUCHI H.

  Department of Applied Physics, Tokyo University of Agriculture and Technology

• NOGUCHI Hajime

  Department of Physics, Aichi-Gakugei University

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