[SHORT REPORTS]Mechanical and Thermal Hyperalgesia Induced by Clioquinol in Rats
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概要
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The purpose of the this study was to clarify the effects of clioquinol (5-chloro-7-iodo-8-hydroxyquinoline, 100 μM) on the pain-related behavior of rats. Three pain tests were used: Paw pressure test and foot immersion tests in hot (46℃) and cold (6℃)water were performed before and each hour after the clioquinol injection. Withdrawal thresholds to mechanical stimuli and withdrawal latencies to heat stimuli significantly decreased 1 and 2 hours after the clioquinol injection. Withdrawal latencies to cold stimuli were not influenced by clioquinol. These results suggest that clioquinol can induce hyperalgesia in rats.
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