EFFECTS OF CISPLATIN ON ERYTHROPOIETIN PRODUCTION IN RATS
スポンサーリンク
概要
- 論文の詳細を見る
The effects of cisplatin on erythropoietin (EPO) production were investigated in comparison with the effects of phenylhydrazine in rats. Cisplatin (4.5 mg/kg i.p. bolus) decreased red blood cell count (RBC), hematocrit (Hct) and hemoglobin concentration (Hgb) for 14 days after dosing. These decreases were accompanied with increases of blood urea nitrogen (BUN) and serum creatinine (s-CRE). Both serum EPO concentration and kidney EPO mRNA content were significantly decreased in cisplatin-treated rats. On the other hand, phenylhydrazine (10 mg/kg p.o. once a day for 8 days) decreased RBC, Hct and Hgb, and increased serum EPO concentration and kidney EPO mRNA content. Phenylhydrazine had little effect on BUN or s-CRE. These results suggest that a suppression of EPO production is involved in the pathophysiology of cisplatin-induced renal anemia and that measurement of serum EPO concentration and kidney EPO mRNA content is available for distinguishing renal anemia from hemolytic anemia.
- 日本トキシコロジー学会の論文
- 1996-08-25
著者
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TERAI Takao
Toxicol. Res. Labs., Fujisawa Pharmaceutical Co., Ltd.
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UNAMI Akira
Toxicology Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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MINE Yasuhiro
Toxicology Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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Terai T
Osaka Inst. Technol. Osaka Jpn
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Sato S
Life-long Sports Core Kanazawa Institute Of Technology
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TAMURA Takayuki
Toxicology Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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Unami Akira
Toxicology Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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Mine Yasuhiro
Toxicicology Research Laboratories Fujisawa Pharmaceutical Co.ltd.
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Sato Susumu
Department Of Precision Mechanics Faculty Of Engineering Kyoto University
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Sato Susumu
Development Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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NISHINA Noriko
Toxicology Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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NODA Kohsei
Toxicology Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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Noda Kohsei
Toxicology Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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Nishina Noriko
Toxicology Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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Tamura Takayuki
Toxicology Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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