METALLOTHIONEIN TRANSGENIC AND KNOCK-OUT MOUSE MODELS IN THE STUDY OF CADMIUM TOXICITY
スポンサーリンク
概要
- 論文の詳細を見る
The role of MT in Cd toxicology has become clearer by the use of MT-I transgenic and MT-I and -II knock-out animals. We have shown that:(1)MT-transgenic and -null mice have altered tissue MT protein levels;(2)MT-transgenic and-null mice appear to be normal in other detoxifyng systems examined, except for slight alterations in tissue Zn concentration;(3)MT does not appear to inhibit Cd absorption from the gestrointestinal tract, nor affect Cd tissue distribution;(4)MT reduces the elimination of Cd from liver;(5)MT protects against acute inorganlc Cd-induced lethality and hepatotoxicity, and the mechanism of the protection appears to be due to its ability to sequester Cd in the cytosol, thus reducing the amunt of Cd in critical organelles;(6)MT modulates Cd-induced expression of protooncogene(c-jin) and tumor suppress genes(p53) in mouse liver;(7)MT does not protect against CdMT-induced acute renal injury, and Zn-induced protection against CdMT-induced acute nephrotoxicity does not appcear to be mediated through MT;(8)Chronic Cd administration produces renal injury inb MT-null mice, indicating that Cd-induced nephrotoxicity is not necessarily mediated through the CdMT complex;(9)MT protects against chronic CdC12 nephropathy, suggesting that intracellular MT is an important adaptive mechanism decreasing CdC12 nephrotoxicity, and that a single injection of CdMT may not be a good model to study chronic Cd nephropathy;(10)genetic background of mouse strains, rather than constitutive MT levels, is a more important determinant for Cd-induced acute testicular injury. In addition to Cd detoxication, MT-transgenic and MT-null mice are also good models to determine other functions of MT. MT plays important roles in maintaining Zn homeostasis and protection against Zn toxicity. Knock-out of the MT gene also renders animals/cells more vulnerable to oxidative stress and DNA alkylating agent-induced toxicity. Therefore, the MT-transgenic and knock-out mouse models provide complementary approaches to those used previously, and have greatly increased our understanding of the role of MT in Cd toxicology, as well as other biological functions of MT.
- 日本トキシコロジー学会の論文
- 1998-07-24
著者
-
KLAASSEN Curtis
Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center
-
LlU Jie
Department of Pharmacology, Toxicology & Therapeutics, University of Kansas Medical Cener
-
Liu Jie
Department Of Cardiology Renmin Hospital Of Wuhan University
-
Liu Jie
Dep. Of Physiology Capital Medical Univ. Chn
-
Klaassen Curtis
Department Of Pharmacology Toxicology & Therapeutics University Of Kansas Medical Cener
関連論文
- P1-80 Involvement of keratinocyte growth factor (KGF) and its receptor (KGFR) in liver regeneration of iron-overloaded after partial hepatectomy
- Steroid 5α-reductase inhibitory activity of condensed tannins from woody plants
- 5α-Reductase Inhibitory Effect of Triterpenoids Isolated from Ganoderma lucidum(Miscellaneous)
- The effect of strain, growth stage, and cultivating condition of Ganoderma lucidum on 5α-reductase inhibition
- Invited Channel Engineering of 3-Nitride HEMTs for Enhanced Device Performance (先端デバイスの基礎と応用に関するアジアワークショップ(AWAD2005))
- Invited Channel Engineering of 3-Nitride HEMTs for Enhanced Device Performance (先端デバイスの基礎と応用に関するアジアワークショップ(AWAD2005))
- Differences in the Changing Trends of Monophasic Action Potential Duration and Effective Refractory Period of the Ventricular Myocardium After Myocardial Infarction in Vivo
- Gender Disparity of Hepatic Lipid Homoeostasis Regulated by the Circadian Clock
- Effect of Gold Coating on Interfacial Reaction between Dental Porcelain and Titanium
- 23pWX-6 Scanning Tunneling Microscopy Investigation of tris(phthalocyaninato)yttrium triple-decker molecules deposited on Au(111)
- ATWS Characteristics of Super LWR with/without Alternative Action
- LOCA Analysis of Super LWR
- Safety of Super LWR, (II) : Safety Analysis at Supercritical Pressure
- Safety of Super LWR, (I) : Safety System Design
- Effects of mechaincal vibration on DNA and proteoglycan syntheses in cultured articular chondrocytes
- Estimates on the Stokes Pressure by Partitioning the Energy of Harmonic Functions(Kyoto Conference on the Navier-Stokes Equations and their Applications)
- Sildenafil Inhibits Human Pulmonary Artery Smooth Muscle Cell Proliferation by Decreasing Capacitative Ca^ Entry
- Upregulation of Tanis mRNA Expression in the Liver is Associated with Insulin Resistance in Rats
- METALLOTHIONEIN TRANSGENIC AND KNOCK-OUT MOUSE MODELS IN THE STUDY OF CADMIUM TOXICITY
- Mechanical Retention of Low-fusing Porcelain to Cast Titanium
- Nasal Natural Killer/T Cell Lymphoma with Cutaneous Involvement : Case Report and Chinese Literature Review Reported in China Mainland
- Immunohistochemical Analysis of Histone H3 Modifications in Germ Cells during Mouse Spermatogenesis
- Proteomic expression analysis of mycosis fungoides (MF) skin tissues : Overexpressions of SOD2, S100A8 and FABP5 in MF
- Simulation of a Single Bubble Rising with Hybrid Particle-Mesh Method
- Low-Temperature Scanning Tunneling Microscopy Investigation of Tris(phthalocyaninato)yttrium Triple-Decker Molecules Deposited on Au(111)
- Quantitative-profiling of bile acids and their conjugates in mouse liver, bile, plasma, and urine using LC-MS/MS
- Stable Circularly Polarized Emission from a Vertical-Cavity Surface-Emitting Laser with a Chiral Reflector
- Comparison of Percutaneous and Open Anterior Screw Fixation in the Treatment of Type II and Rostral Type III Odontoid Fractures
- Electrochemical Behavior and Voltammetric Determination of Theophylline at a Glassy Carbon Electrode Modified with Graphene/Nafion