THE RATIONALE FOR USING LOGARITHMIC TRANSFORMATION OF CONCENTRATION DATA IN TOXICOKINETIC STUDIES

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概要

• 論文の詳細を見る

• The present paper focuses on the necessity of logarithmic transformation of plasma concentration in toxicokinetic studies. The dose-plasma concentration relationship is the most important subject to be studied, because test doses rise over a wide range from therapeutic dose level to toxic dose level in toxicity studies. It is concluded that the logarithmic transformation of concentration data effectively stabilized the variances, and the regression analysis of log-transformed data makes it possible to quantitatively evaluate the magnitude of non-linear kinetics of test compounds in toxicity studies.

• 日本トキシコロジー学会の論文
• 1995-02-25

著者

• Igarashi Toshiji

  Department Of R&ampd Information Management Eisai Co. Ltd

• Igarashi Toshiji

  Department Of Drug Safety Research. Eisai Co. Ltd.

• Igarashi Toshiji

  Department Of Drug Safety Research Eisai Co. Ltd.

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