エブネル腺アミラーゼ分泌における自律神経性調節に関する研究
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To evaluate the role of autonomic regulation of von Ebner's glands, the effects of autonomic agents on the amylase activity and on the amylase secretion of von Ebner's glands, and the effects of autonomic blocking agents on the amylase activity of von Ebner's glands after feeding were compared with the effects on the parotid glands and pancreas in the same rats. By the administration of the β-adrenergic agonist, isoproterenol, the amylase activity greatly decreased in parotid glands, while it decreased slightly in von Ebner's glands and pancreas. The administration of the muscarinic cholinergic agonist, pilocarpine did not change the amylase activity in parotid glands, while it greatly decreased the amylase activity in both von Ebner's gland and pancreas. Under anesthesia with sodium pentobarbital, von Ebner's glands constantly secreted saliva during resting, and both the salivary flow rate and amylase secretion of von Ebner's gland by pilocarpine administration were larger than those by isoproterenol administration. The reduction in the amylase activity of parotid glands after feeding was reversed by prior administration of the β-adrenergic antagonist, propranolol. However, propranolol administration did not change the effect of feeding on amylase activity in von Ebner's glands and pancreas. Prior administration of the muscarinic cholinergic antagonist, atropine did not affect the reduction of amylase activity in parotid glands after 1 hr feeding, while it completely inhibited the effect of feeding on the amylase activity in both von Ebner's gland and pancreas. In morphologic observation, feeding reduced the secretory granules in the acini of von Ebner's glands, and the reduction of granules was blocked by prior administration of atropine, and not by propranolol. The change in number of secretory granules was similar to the change in the amylase activity. These results suggest that the amylase secretion from von Ebner's glands during feeding was mainly regulated by a muscarinic cholinergic rather than a β-adrenergic mechanism, and that von Ebner's glands secrete saliva into the groove of the circumvallate and foliate papillae.
- 北海道医療大学の論文
- 1994-06-30
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