11 変形性関節症マウス顎関節におけるMMP-3とTIMP-2の発現と局在(第469回 大阪歯科学会例会)

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概要

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• I used histological and immunohistochemical methods, and enzymography to investigate the expression and localization of MMP-3 and TIMP-2 in the temporomandibular joint (TMJ) of male ICR mice, which are typical osteoarthritis models.Toluidineblue stains showed glycosaminoglycans forming proteoglycans were decreased in the surface cartilage toward the end of the experiment.Immunohistochemistry revealed MMP-3 was positive in the surface cartilage of the TMJ.The distribution of TIMP-2 was similar to that of MMP-3.ProMMP-3, the active form of MMP-3, and TIMP-2-MMP-3 complex were detected in the cartilage and / or the mixture of the disc and synovium with immunoblotting and enzymography.These results suggest that the balance between MMP-3 and TIMP-2 are disrupted in the surface of the osteoarthritic cartilage and the imbalance triggers progressive osteoarthritis.

• 大阪歯科学会の論文
• 2000-03-25

著者

• 酒匂 潤

  大阪歯大・大学院・口腔外科第1

関連論文

• Expression and localization of MMP-3 and TIMP-2 in the temporomandibular joint of osteoarthritic mice(変形性関節症マウス顎関節におけるMMP-3とTIMP-2の発現と局在)(大阪歯科大学大学院歯学研究科博士(歯学)学位論文内容要旨および論文審査結果要旨の公表)
• 11 変形性関節症マウス顎関節におけるMMP-3とTIMP-2の発現と局在(第469回 大阪歯科学会例会)

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