4 歯髄の石灰化に対する生体内物質の調節作用 (第417回 大阪歯科学会例会)

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概要

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• Human pulp tibroblasts (HPF-C) were isolated from deciduous teeth and cultured in vitro. With continued culture in normal tissue culture medium, six pulp fibroblast strains formed mineralized nodules. HPF-C showed high levels of alkaline phosphatase activity that could be increased more than seven fold by the addition of 1,25 (OH)_2D_3 at 5-50×10^<-9>. In addition to the production of type I collagen, these cells also synthesized fibronectin and osteonectin, and expressed mRNA of transforming growth factortype B and liver / bone / kidney alkaline phosphatase. The responses of HPF-C to parathyroid hormone, cAMP and calcitonin were similar to that of odontoblasts. Also, HPF-C in contact with hydroxyapatite served as a mediator of cell-to-cell interaction and was related to the functional differentiation of cells for tissue repair, including pulpal calcification.

• 大阪歯科学会の論文
• 1992-10-25

著者

• 塚本 芳雄

  大阪歯大・薬理

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