Effects of Sucralfate, Magnesium Oxide and Sodium Ferrous Citrate on Sparfloxacin Pharmacokinetics

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The effects of sucralfate, magnesium oxide and sodium ferrous citrate on the pharmacokinetics of sparfloxacin were studied in 6 healthy subjects. According to a four-way crossover design, each subject received the following drug combinations in a random order : (A) a single 200 mg dose of sparfloxacin alone ; (B) a single 200 mg dose of sparfloxacin with a 900 mg dose of sucralfate ; (C) a single 200 mg dose of sparfloxacin with a 1 g dose of magnesium oxide ; (D) a single 200 mg dose of sparfloxacin with a 100 mg dose of sodium ferrous citrate. The four regimens were given to subjects in the fasting state. Blood samples were collected over a 24- hour period, and plasma concentrations of sparfloxacin were determined by high-performance liquid chromatography. The area under the curve from 0 to 24 hours (AUC_<0-24>) for sparfloxacin for regimen B was significantly lower (52.9% less, p<0.005) than that for regimen A. However, for regimens C and D, the reductions in AUC_<0-24> as compared with regimen A were not significant (19.4% and 28.2%, respectively). Also, the peak plasma concentrations (Cmax) of sparfloxacin for regimens B and D were significantly lower (54.7% less, p&ly;0.001 and 31.4% less, p<0.05, respectively) than that for regimen A. However, the Cmax for regimen C was not significantly lower than that for regimen A (22.1% less). These results suggest that aluminum containing drugs should not be given in combination with sparfloxacin.
日本医療薬学会の論文
2004-01-10

Effects of Sucralfate, Magnesium Oxide and Sodium Ferrous Citrate on Sparfloxacin Pharmacokinetics

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