レボフロキサシン及びスパルフロキサシンの尿中排泄に及ぼすマグネシウムイオン及びアルミニウムイオンの影響
スポンサーリンク
概要
- 論文の詳細を見る
Levofloxacin (LVFX) is a rapidly absorbed new quinolone and (S)-( - )-ofloxacin. The effects of metal cations on the urinary excretion of Levofloxacin (LVFX) were investigated in five healthy volunteers at the time of differential administration by measuring the unmetabolites of LVFX in urine and the findings of LVFX were then compared with those of long-acting Sparfioxacin (SPFX). Magnesium oxide (MgO) containing Mg^2+ and sucralfate containing Al^3+ are examined as metal cations. Urine samples were collected for 10 and 24 hours after a single oral administration of LVFX and SPFX, respectively. The unmetabolites concentrations of LVFX and SPFX in urine were determined using HPLC. The urinary excretion of LVFX decreased significantly after the simultaneous administration with MgO and sucralfate and at 1 hour after the administration of LVFX (p< 0.05) but was not affected at 2 hours after administration. The administration of MgO and sucralfate within 2 hours after the administration of SPFX resulted in a significant decrease in SPFX urinary excretion (p< 0.05). However, the decrease in SPFC urinary excretion was less than that in LVFX. Sucralfate decreased the LVFX urinary excretion more than MgO although the difference was not significant. The effect of sucralfate on SPFX urinary excretion was the same as that for MgO. These results suggest that the interactions between LVFX and metal cations are avoidable by the administration of metal cations at 2 hours after the administration of LVFX and the administration of metal cations must be avoidable within 2 hours after the administration of SPFX.
- 日本医療薬学会の論文
- 2002-04-10
著者
関連論文
- レボフロキサシン及びスパルフロキサシンの尿中排泄に及ぼすマグネシウムイオン及びアルミニウムイオンの影響
- P-154 インスリン抵抗性 II 型糖尿病に塩酸ピオグリタゾンが奏効した症例
- 日本人パラメータを用いたTDM支援ソフトの作成
- P-34 Simplex Method を用いた薬物体内動態解析ソフトの作成
- P-158 QC (Quality Control) 的問題解決法を用いた調剤過誤対策
- P-425 Phenytoin の非定常状態の解析ソフト (Excel VBA) の作成
- P-414 受容体占有理論に基づくスルホニルウレア剤の考察
- P-255 薬物血中濃度解析プログラムの機能拡張とその考察