膜電位依存性イオンチャネルの開機構に対する水の効果

概要

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Historical works addressed to elucidating roles of water on a gating process of voltate-gated ion channels were critically reviewed. My recent works on squid sodium channels showed a unified interpretation about these preceding works. i. e. viscosity or osmolarity models. A water-nonelectrolytes mixture solvent affects a voltage-dependent process accompanying gating currents viscosity-dependently and a final step to open osmolarity-dependently. In the latter step, a transient hydration of around 5 water molecules in the pore was essential.
2000-05-25