培養脳スライスにおいてもニューロンの発芽は起こるか?

概要

論文の詳細を見る
Axonal sprouting is a form of morphological plastic change of the neurons. It is proposed to underlie long-term changes in brain function and take place even in mature brain. Electriphysiological analysis revealed that chronic stress and antidepressants induce axonal degeneration and sprouting of locus coeruleus noradrenergic neurons in adult rat brain, respectively. Sprouing of hippocampal neurons was represented in the slice cultures of the hippocampus from 1-week old rat. This phenomenon was found to be specific for CA3 pyramidal neurons. Possible molecular mechanisms for neuron-specific morphological plasticity are discussed, referring to results from other laboratories.
日本生物物理学会の論文
1996-07-25