ミオシン首振り説 : 部位特異的変異による検証から構造遺伝学によるメカニズム解明へ

概要

論文の詳細を見る
Myosin is a molecular motor that drives movement of actin filaments. It was recently established that the myosin head undergoes a major shape change during the ATP hydrolysis cycle, leading to the popular hypothesis that the shape change provides motile force. Cellular slime mold is uniquely useful not only as an expression system of site-directed mutant myosins, but also as a genetic system to isolate specific mutant myosin genes and their suppressors out of a population of randomly mutagenized cells. Here we present the power of both site-directed and random approaches to investigate the significance and mechanism of the conformational changes.
日本生物物理学会の論文
1997-01-25