ニューロンレベルでの摂食行動調節機構

概要

論文の詳細を見る
Feeding behavior is regulated and conducted by the neuronal circuits of the lateral hypothalamus (LH) and the ventromedical hypothalamus (VMH) as main constiuents. We have been using the folloeing techniques in order to make clear the regulative system of feeding behavior neurophysiologically. One of them is the technique of applying chemicals directly to neurons by using the multi-barreled microelectrodes. Wehave been studying the action of acetylcholine, noradrenaline, dopamine and so on. Dopamin, in particular, may give us a clue to understand the pathophysiology of anorexia nervosa. The second in the way of studying the connection between the hypothalamus and other neural elements electrophysiolofically and by this technique we have made clear the morphological and functional relationship ofnthe frontal cortex the limbic system with LH. The thierd trchnique is to obserbe of neuronal sctivity in conscious animals druging food intake behavior. By this technique we can make clear where the motivation, the anticipation and the integration for feeding behavior are formed. But we cannot understand the whole regulative mechanism of feeding behavior only by subdividing the feeding behavior into the neuronal level. It is imporatant to associate this behavior with the result of stimulation experiments, destructive experiments, druginjection experiments and clinical cases in the future.
日本心身医学会の論文
1978-04-01