緊張型頭痛患者における心理状態と免疫機能に関する検討

概要

論文の詳細を見る
Recently the effects of stress on the immune system are drawing our attention. In order to evaluate the effects of state of mind on the immune system in patients with tension-type headache, I investigated female patients without organic disorders and female controls. Hamilton depression scale was utilized to distinguish the patients with depressed state from those without depressed state. Immune system-associated antigens expressed by peripheral blood lymphocytes were examined using flow cytometory in three pairs of monoclonal antibodies (anti T/B cell, anti Helper/Suppressor cell, and anti CD 4/HLA-DR), which were labeled by fluorescence (FITC and PE). T cell and Suppressor cell were decreased in both groups of patients. Helper/Suppressor cell ratio (H/S ratio) was higher in the depressed patients group than other two groups. It was reported by Teshima et al. that stress induced decrease of Suppressor cell and increase of H/S ratio. In this study H/S ratio increased in the depressed patients group. HLA-DR is specific for activated T cell. In the depressed patients group HLA-DR+ cell was decreased and so low activity of T cell was expected. On the other hand, the immune activity in the non-depressed patients group was not always low. These results support the concept that emotional state may significantly alter the immune activity in patients similarly suffering from tension-type headache.
日本心身医学会の論文
1993-08-01