Association of Bone Mineral Density with Polymorphism of the Human Calcium-Sensing Receptor Locus

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概要

• 論文の詳細を見る

• A strong correlation between bone mass and genetic factors has been shown in twins and family studies. Some of the genes involved would regulate bone metabolism, bone formation, and resorption, all processes that determine bone mass. One candidate genes, calcium-sensing receptor (CASR) in the parathyroid gland, regulates calcium homeostasis by sensing decreases in extracellular calcium level and effecting an increase in secretion of parathyroid hormone (PTH) and calcium (Ca) reabsorption in the kidney. We have investigated a possible association between the CA-repeat polymorphism at the human CASR gene locus and the bone mineral density (BMD) of radial bone in 472 postmenopausal Japanese women. Genotypes were classified into nine groups according to the number of CA repeats present, from 20 to 12. BMD was expressed as the adjusted BMD, which was the body mass index (BMI), and age-adjusted average BMD. The 247 women who had an A3 allele (228 bp, containing 18 repeats of CA) had significantly lower adjusted BMD (mean±SD : 0.303±0.059 versus 0.316±0.063g/cm^2; P=0.0308) than the participants (n=201) who did not carry an allele of that size. This result suggests that genetic variation at the CASR gene locus is associated with some determinants for BMD in postmenopausal women.

• 日本医科大学の論文
• 2001-03-25

著者

• Nakajima T.

  Department of Ischemic Circulatory Physiology, The University of Tokyo

• Yoshida H.

  Tokyo Tech.

• Orimo H.

  Department Of Geriatrics Faculty Of Medicine University Of Tokyo

• SUZUKI T.

  Tokyo Metropolitan Institute of Gerontology

• Miyao M.

  Department Of Electronics Kyushu University

• Miyao M.

  Department Of Geriatrics Faculty Of Medicine University Of Tokyo

• Tsukamoto K.

  Department of Molecular Biology, Institute of Gerontology, Nippon Medical School

• Hosoi T.

  Department of Geriatrics, Faculty of Medicine, University of Tokyo

• Ota N.

  Department of Molecular Biology, Institute of Gerontology, Nippon Medical School

• Watanabe S.

  Tokyo Metropolitan Institute of Gerontology and Hospital

• Emi M.

  Department of Molecular Biology, Institute of Gerontology, Nippon Medical School

• Nakajima T.

  Department of Chemistry, Faculity of Science, Kyoto University

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