視床下部c-fos蛋白消長に対する寒冷暴露前の運動トレーニングの影響について(平成13年度大学院スポーツ科学研究科修士論文概要)
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Endurance exercise-training produces cold tolerance which has been known as a positive cross adaptation. The purpose of the present investigation was to examine if the differences of neural activation in the nucleus of hypothalamus of rats, ventromedial preoptic nucleus (VMPO), supraoptic nucleus (SO), and suprachiasmatic nucleus (SCH) by cold exposure existed between exercise-trained and un-trained rats. Wistar rats(n = 30, 6 weeks of age) were divided into trained (n = 15) and untrained (n = 15) groups. The training group was counducted an exercise-training program on a treadmill 5 days/wk during the dark phase of the light-dark cycle with 2 days rest on the weekend for a period of 3 wk. The speed and grade of treadmill were gradually increased to the final setting of 18m/min at 8% grade. Then both groups were further divided into 5 groups based on the periods of cold exposure: control (no exposure, n = 3), 3 hours (n = 3), 1 day (n = 3), 7 days (n = 3), and 14 days (n = 3), (total 10 groups). The food intake and body weight were measured from 8-weeks old. c-fos immunohistochemistry was used to identify neuronal regions activated by afferent stimulation, c-fos positive density (counts/mm2) of three regions in hypothalamus displayed significant difference between trained and untrained rats (3h in SO; 7days in VMPO; 14days in SCH). The trained group tended to inhibit c-fos expression in VMPO and to facilitate it in SO as compared with untrained. As the periods of cold exposure increased, both changes of c-fos expression in SCH and weight gain showed different trends between trained and untrained groups. Trained-group showed significantly increased c-fos expression in SCH and weight gain but not untrained. These results suggested that exercise-training directly or indirectly might induce changes in the functions of hypothalamus nucleus against cold exposure.
- 大阪体育大学の論文
- 2002-07-01
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- 視床下部c-fos蛋白消長に対する寒冷暴露前の運動トレーニングの影響について(平成13年度大学院スポーツ科学研究科修士論文概要)
- 視床下部c-fos蛋白消長に対する寒冷暴露前の運動トレーニングの影響について