<原著>小児血管性紫斑病における腎糸球体病変の電子顕微鏡ならびに電顕酵素抗体法による研究 : electron dense deposit, IgAならびにIgGの局在について

概要

論文の詳細を見る
Thirty-nine renal biopsies from patients with anaphylactoid purpura and anaphylactoid purpura nephritis were examined by using light microscopy, electron microscopy, immunofluorescence method and immunoperoxidase method. The electron dense deposits were recognized in mesangial, subendothelial spaces of the glomerular basement membrane and subepithelial region. The subepithelial deposits are related to the nephrotic syndrome. The nephrotic syndrome remained persistent, for patients had the peripheral subepithelial deposits, but it was transient, for patients had the subepithelial deposits only in the paramesangial region. It was considered that the lamellar glomerular basement membrane in 2 cases was significantly deteriorated lesions. In electron immunoperoxidase method, IgA was recognized mainly in mesangial and subendothelial spaces, but IgG mainly in subepithelial space. As it was considered that subepithelial electron dense deposits or deposits related with IgG are mediated by immune complex, the cases for anaphylactoid purpura nephritis being mediated by immune complex, in part at least, are presented.
近畿大学の論文
1980-06-25