クロスチェックによるカネミ油症ライスオイル中PCDD, PCDF及びPCBの分析

概要

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One bottle of Yusho rice oil was obtained from a Yusho family in Fukuoka Prefecture in1998. The concentrations of polychlorinated dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs) and biphenyls (PCBs) in the causal oil were analyzed with two different approaches for cross-checking and the obtained results agreed well. The individual concentrations of all the 17 2,3,7,8-substituted PCDD/F and 14 coplanar PCB (Co-PCB) congeners were elucidated for the first time. The PCDD, PCDF and PCB concentrations were found to be 0.60, 8.8 and 850 ppm, respectively. It was confirmed that PCDFs play a major role in the toxicity of Yusho oil. Based on our data, the smallest TEQ intake during the latent period was estimated to be 0.067 mg for Yusho patients. This value is approximately 60% of that previously reported, thus suggesting a lower minimum threshold level for the development of the toxic symptoms of Yusho. This information will be useful in the human health risk assessment of PCDD/Fs and PCBs.
横浜国立大学の論文