アミノ・カルボニル反応生成物等の有胞子細菌等に対する生理活性

概要

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Bacillus coagulans IAM 1146 can not propagate on a synthetic medium supplemented by such mild inhibitors as about 0.35 moles of sodium acetate or other neutral salts or 0.002% of nitrofurylacrylamide, unless components of the medium were autoclaved altogether. Separately autoclaved synthetic agar medium was inoculated with washed spores of Bacillus coagulans IAM 1146,mixed and poured into a Petei dish. After solidified, pulp disc with 20μl of test solution was put on the agar surface, and the dish was incubated at 45℃ for 1 to 3 days. Bacterial colonies were developed around the pulp disc with the following solutions : 1) Maillard substances prepared from sodium glutamate and various sugars; glucose and p-aminobenzoic acid or amino acids except serine, threonine, valine, leucine, isoleucine, lysine, cystine, phenylalanine, tyrosine, tryptophane and proline. 2) Histidine, arginine, cysteine, ascorbic acid, erithorbic acid and sodium thioglycollate. 3) Peptone and yeast extract. 4) Fe^<3+>, Fe^<2+>, Mn^<2+> and their chelated compounds. Bacillus cereus, Serratia marcescens and even Saccharomyces cerevisiae, which are not sensitive to "iron transport compounds" naturally, are forced to respond to the above mentioned inducers, if proper in hibitors were chosen.
山梨大学の論文