<論文>2置換β-およびγ-シクロデキストリンにおけるアントラニル酸修飾残基の二次元1H-NMRおよび吸収スペクトル挙動

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Two-dimensional IH_NMR spectra (2D-1H-NMR) of 6A,6B_; 6A,6c_; and 6A,6D_bis anthranilateβ-cyclodextrins (β-I, β-2, and β-3, respectively) and 6A,6B_; 6A,6c_; 6A,6D_; and 6A,6E _bis anthranilateγ-cyclodextrins (γ-I, γ-2, γ-3, and γ-4, respectively) have been measured to consider the interaction of twoanthranilate moieties. 2D-1H-NMR ofthose compounds obtained by H-H cosy method indicated that theinteraction of two appended moieties is interacted each other, because 2D-1H-NMR of those hosts showedthat degree of overlap of two appended moieties was extended in the order β-1>β-2>β-3 andγ-I>γ-2>γ-3>γ-4. It suggests that two appended moieties depended on how much fur away each other canmove easily toward inside or outside ofcavity ofcyclodextrin. The UV-Vis spectra ofthose hosts with theguest such as bile acid are changed with isosbestic points. The results obtained from2D-1H-NMR andUV-Vis spectra describe that the binding mechanism of those hosts are undergoing with induced-fit type ofhost-guest complexes.