Secretion of Gut GLI and Glicentin

概要

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Intraluminal administration of nutrients to piglets elicited an enhancement of glicentin secretion. These results correspond with the findings obtained in experiments with dogs in terms of gut glucagon-like immunoreactivity (GLI). Although the response of pancreatic glucagon to hypoglycemia is well known, the experiment with piglets demonstrated the secretion of gut glicentin in response to hypoglycemia. Other experiments with dogs indicated that GLI secretion in response to hypoglycemia or neuroglycopenia is regulated by the parasympathetic system. However, in the postprandial state, the effect of the nervous system is weak and is overcome by the secretion of glicentin in response to the intraluminal nutrients. Ileojejunal transposition revealed intestinal adaptation, where an elevated plasma glicentin or GLI, thickening of the intestinal mucosa and an increased content of glicentin in the intestine were observed. The response of gut GLI to glucose was also exaggerated in the ileojejunal transposition dogs. These results suggest that the animal model with intestinal adaptation such as ileojejunal transposition will be useful for further research on glicentin secretion.
東北大学の論文