<原著>有機陰イオンの肝細胞より胆汁への排泄機構 : HMG-CoA還元酵素阻害剤, プラバスタチンを用いた研究
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概要
- 論文の詳細を見る
To clarify the transport mechanism of organic anions, biliary excretion of sodium(+)-(3R, 5R)-3,5- dihydroxy-7-[(1S, 2S, 6S, 8S, 8aR)-6-hydroxy-2-methyl-8-[(S)-2-methylbutyryloxy]-1,2,6,7,8,8a-hexahydro-1-naphthyl] heptanoate (pravastatin) and its in vitro uptake into rat liver plasma membrane vesicles were investigated. After injection of 30 μmoles of pravastatin through the cervical vein of the rat, cumulative biliary excretion of pravastatin in 35 min was 70% in Sprague-Dawley rats (SD rats) and 15% in Eisai hyperbilirubinuria rats (EHBR). When the in vitro uptake of pravastatin by rat liver canalicular membrane vesicles was determined by a rapid filtration technique, ATP-dependent uptake of pravastatin by the vesicles was similarly observed in the two strains of rats. These findings suggest that pravastatin is transported through the hepatocyte canalicular membrane of EHBR as well as SD rats by a transporter different from the multispecific organic anion transporter.
- 近畿大学の論文
- 1995-12-25