<原著>アトピー性皮膚炎患者皮膚表皮の最終分化産物の異常について
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概要
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Filaggrin, cystatin A and involucrin are the principal products of epidermal terminal differentiation. They are required for normal formation of the stratum corneum. However the surface of the skin of patients with atopic dermatitis is always dry and easily becomes itchy, indicating abnormal stratum corneum formation. This study investigated the cause of the dryness of the skin surface in patients with atopic dermatitis. Paraffin-embedded sections of specimens of skin obtained from 27 patients with atopic dermatitis were labelled with anti-human filaggrin, anti-human cystatin A and anti-human involucrin antibodies, and the amounts of reaction products were determined using a chromato-scanning meter. The amount of filaggrin was 4.89±0.36 g (n=12) in control skin (NS). In contrast, there were respectively 2.40±0.37μg (n=12) and 2.91±0.40μg (n=4) of filaggrin in lesional skin (AD-L) and non-lesional skin (AD-NL) of atopic dermatitis patients. The differences between NS and AD-L and between NS and AD-NL were statistically significant (P<0.001,student t-test). The amount of cystatin A was 4.23±0.37μg (n=9) in control skin (NS) and 3.95±0.14μg (n=4) in AD-NL, but 2.13±0.22μg (n=16) in AD-L. The difference between NS and AD-L was statistically significant. The amount of involucrin was 3.31±0.57μg (n=10) in NS, 3.14±0.54μg (n=4) in AD-NL, 2.36±0.36μg (n=16) in AD-L. There were no statistically significant differences between either NS and AD-L or NS and AD-NL in amount of involucrin. These findings suggest that a decrease in the amount of filaggrin, which is the precursor protein for emollient factor (free amino acids) in the stratum corneum, may be one of the causes of dry skin in patients with atopic dermatitis.
- 近畿大学の論文
- 1993-12-25